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Coverage of the 2017 Conference on Retroviruses and Opportunistic Infections

HIVandHepatitis.com coverage of the 2017 Conference on Retroviruses and Opportunistic Infections, February 13-16, 2017, in Seattle.

Antiretroviral Therapy and Treatment Strategies

• Several New Candidates in HIV Drug Pipeline Discussed at Conference
• Dolutegravir Monotherapy Fails to Maintain Viral Suppression
• Integrase Inhibitors May Increase Risk of IRIS in Late Presenters for HIV Treatment
• New HIV Capsid Inhibitors Show High Potency and Prolonged Activity in Early Studies
• Treatment-as-Prevention Study Sees Substantial Drug Resistance, but No Impact on HIV Therapy
• Monoclonal Antibodies Show Promise for HIV+ People with Few Treatment Options
• New NNRTI Doravirine Shows Good Efficacy in Phase 3 Study
• Efavirenz/Tenofovir/Emtricitabine Less Likely to Cause Adverse Birth Outcomes
• Dual Antiretroviral Regimen Maintains Durable HIV Suppression after Switch
• Integrase Inhibitor Bictegravir Matches Dolutegravir for First-Line HIV Treatment
• Infants Treated Within Days of Birth Can Clear HIV Reservoir Rapidly

HIV Cure Research

• Timothy Brown, the Berlin Patient, Celebrates a Decade Cured of HIV
• How Does Vedolizumab Antibody Therapy Lead to Sustained Viral Remission?
• Bone Marrow Transplant Patient Off ART for 288 Days Without HIV Rebound
• Spanish HIV Vaccine Induces Control Off ART in Nearly 40% of Recipients
• Infants Treated Within Days of Birth Can Clear HIV Reservoir Rapidly

HIV Prevention

• Bacterial Vaginosis Does Not Affect Efficacy of Oral PrEP in Women
• STI Rates Among PrEP Users Are High, But Evidence that PrEP Increases Them Is Inconclusive
• Unique Case of PrEP Failure Without Drug Resistance Reported in Amsterdam
• STI Prophylaxis in PrEP Users Reduces Syphilis and Chlamydia, but Not Gonorrhea

HIV-Related Conditions and Complications

• Better Depression Care Could Improve Outcomes for HIV Treatment Programs
• Long-Term Darunavir/Ritonavir Modestly Increases Risk of Cardiovascular Disease
• Bone Density Improves in People Who Switch from Tenofovir DF to Tenofovir Alafenamide
• Studies Look at Brain and Cognitive Changes in People with HIV As They Age
• Stopping Smoking Cuts Risk of Some Cancers Quickly in People with HIV
• Treatment or Watchful Waiting for Cervical Abnormalities in Women with HIV?

HIV Epidemiology and Access to Care

• HIV's Milder Cousin May Be Less Mild than Previously Thought
• Accelerated Linkage to HIV Care Improves Retention by a Third
• Treat and Treat Study Shows Second Phase Is Finding More People with HIV
• Finding Men with HIV -- and Keeping Them in Treatment
• 1 in 5 HIV+ Men in U.K. Who Say They Are Heterosexual Caught HIV from Another Man
• Simple Risk Score Can Identify Gay Men Who May Have Acute HIV Infection
• Peer Navigators Improve Linkage to HIV Care and Retention in South African Study
• Point-of-Care Testing Improves Infant HIV Diagnosis Rate, Treatment, and Retention
• Will There Be a New Wave of HIV Among People Who Inject Drugs in the U.S.?
• How Should HIV Self-Testing Be Provided?
• Time with Transmissible HIV Viral Load Has Fallen By Three-Quarters Since 2000
• Science, Community, and Political Will Can End HIV Epidemic, Says New York Commissioner
• New HIV Infections Fall in the U.S. but Disparities Remain
• Changes In Viral Suppression Over Time Reveal Disparities in HIV Care
• A Combination of Factors Has Reduced HIV Infections in Hard-Hit Part of Africa

Hepatitis C and HIV/HCV Coinfection

• Hepatitis C Treatment Can Be Provided Successfully at Syringe Exchange Sites
• Higher than Expected HCV Prevalence Among HIV-Negative Gay Men in Amsterdam PrEP Program
• DAA Therapy Cures HIV/HCV Coinfected People with Decompensated Cirrhosis or Transplants
• Are HIV/HCV Coinfected People Cured with DAAs at Increased Risk for Liver Cancer?
• Glecaprevir/Pibrentasvir for HCV Can Be Safely Administered with Common Antiretrovirals
• New HCV Infections Among HIV+ Gay Men Drop By Half After DAA Roll-Out in Netherlands

Tuberculosis

• Prednisone Reduces Risk of Developing TB-IRIS after Starting Antiretroviral Treatment
• Isoniazid Preventive Therapy for TB Reduces Risk of Death for People Living with HIV
• Triple Tuberculosis Regimen Beats XDR-TB in First Trial